1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)-
N-Boc-L-2-piperidinecarboxamide
CAS: 78058-41-0
Molecular Formula: C11H20N2O3
1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)- - Names and Identifiers
| Name | N-Boc-L-2-piperidinecarboxamide |
| Synonyms | (S)-1-N-BOC-PIPECOLAMIDE N-BOC-L-2-PIPERIDINECARBOXAMIDE N-Boc-L-2-piperidinecarboxamide (S)-1-Boc-2-piperidinecarboxaMide (S)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE (S)-1-Boc-2-(aminocarbonyl)piperidine (S)-tert-butyl 2-carbaMoylpiperidine-1-carboxylate tert-Butyl (2S)-2-carbamoylpiperidine-1-carboxylate (S)-2-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)- |
| CAS | 78058-41-0 |
| InChI | InChI=1/C11H20N2O3/c1-11(2,3)16-10(15)13-7-5-4-6-8(13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14)/t8-/m0/s1 |
1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)- - Physico-chemical Properties
| Molecular Formula | C11H20N2O3 |
| Molar Mass | 228.29 |
| Density | 1.123g/cm3 |
| Boling Point | 384.4°C at 760 mmHg |
| Flash Point | 186.3°C |
| Vapor Presure | 4.1E-06mmHg at 25°C |
| Refractive Index | 1.498 |
1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2S)- - Introduction
N-Boc-L-2-piperidinecarboxamide(N-Boc-L-2-piperidinecarboxamide) is an organic compound. Its structural formula is R-NH-C(= O)-N(R')R ", where Boc represents a propyl ester protecting group (tert-butoxycarbonyl) and 2-piperidinecarboxamide is the piperidine ring in its structure.
N-Boc-L-2-piperidinecarboxamide is a white crystalline solid, soluble in organic solvents such as methylene chloride and ethanol. It is stable at room temperature and can be stored for a long time under dry conditions.
N-Boc-L-2-piperidinecarboxamide has a wide range of applications in organic synthesis. It is often used as a building block for L-enantioselective reagents and substitution reagents. It can also be used as an intermediate in the synthesis of drug molecules, natural products, and other organic compounds. Because its structure contains a piperidine ring, it can also be used as a detector for chemical analysis and biological experiments.
The preparation of the N-Boc-L-2-piperidinecarboxamide is generally achieved by reacting L-2-piperidinecarboxamide with Boc anhydride. L-2-piperidinecarboxamide is first reacted with N,N-dimethylcarbamic acid (DMAP) and diethylaminotetrahydrofuran (DETHF) to form an intermediate, followed by the addition of tert-butanol acid chloride (BOC-Cl) to protect the amino group to give the N-Boc-L-2-piperidinecarboxamide.
Regarding safety information, N-Boc-L-2-piperidinecarboxamide are generally low-toxic compounds. However, any chemical substance should be handled with caution. Wear appropriate personal protective equipment such as lab gloves and goggles during operation. At the same time, care should be taken to avoid inhalation, ingestion or contact with the skin. In the event of accidental contact or ingestion, seek immediate medical attention and provide compound information.
N-Boc-L-2-piperidinecarboxamide is a white crystalline solid, soluble in organic solvents such as methylene chloride and ethanol. It is stable at room temperature and can be stored for a long time under dry conditions.
N-Boc-L-2-piperidinecarboxamide has a wide range of applications in organic synthesis. It is often used as a building block for L-enantioselective reagents and substitution reagents. It can also be used as an intermediate in the synthesis of drug molecules, natural products, and other organic compounds. Because its structure contains a piperidine ring, it can also be used as a detector for chemical analysis and biological experiments.
The preparation of the N-Boc-L-2-piperidinecarboxamide is generally achieved by reacting L-2-piperidinecarboxamide with Boc anhydride. L-2-piperidinecarboxamide is first reacted with N,N-dimethylcarbamic acid (DMAP) and diethylaminotetrahydrofuran (DETHF) to form an intermediate, followed by the addition of tert-butanol acid chloride (BOC-Cl) to protect the amino group to give the N-Boc-L-2-piperidinecarboxamide.
Regarding safety information, N-Boc-L-2-piperidinecarboxamide are generally low-toxic compounds. However, any chemical substance should be handled with caution. Wear appropriate personal protective equipment such as lab gloves and goggles during operation. At the same time, care should be taken to avoid inhalation, ingestion or contact with the skin. In the event of accidental contact or ingestion, seek immediate medical attention and provide compound information.
Last Update：2024-04-09 21:11:58
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